Journal article
Hippocampal size anomalies in a community-based cohort with childhood-onset epilepsy
AT Berg, HR Pardoe, RK Fulbright, SU Schuele, GD Jackson
Neurology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2011
Abstract
OBJECTIVES:: Epidemiologic evidence suggests the natural history of refractory mesial temporal lobe epilepsy is complicated, yet little is known about the hippocampus from the nontertiary center perspective. Methods: In a community-based cohort, individuals with nonsyndromic focal epilepsy with onset 1.96; 10 (9%) with ZHC <-1.96. By contrast, 2/63 (3%) controls had extreme values (p = 0.001). Within the unknown cause group, temporal lobe epilepsy (TLE) cases were more likely to have extreme hippocampal volumes than non-TLE (31% vs 15%, p = 0.03). Extreme volumes were generally interpreted as normal visually. These anomalies were not associated with seizure remission or pharmacoresistance. C..
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Awarded by National Institute of Neurological Disorders and Stroke
Funding Acknowledgements
[ "Supported by a grant from the National Institutes of Health, NINDS R37-NS31146; a Victorian Life Sciences Computation Initiative (VLSCI) grant number VR0056 on its Peak Computing Facility at the University of Melbourne, an initiative of the Victorian Government; the Victorian Government's Operational Infrastructure Support Program; and NHMRC program grant number 400121.", "Dr. Berg receives research support from the NIH/NINDS; has received funding for travel and speaker honoraria from Eisai Inc., the British Pediatric Neurological Association, and the Epilepsy Research Center (Melbourne); has received funding for travel from UCB, the American Epilepsy Society, and the International League Against Epilepsy; has received awards from the American Epilepsy Society and British Pediatric Neurological Association; has served as a consultant for Dow Agro Science; serves on the editorial boards of Epileptic Disorders and Epilepsy & Behavior; and is past Chair of the ILAE's Commission on Classification and Terminology, current Chair of the ILAE's Task Force on Classification-Diagnostic Manual, member of the ILAE's Pediatric Commission's Task Force on Autism, member of the AES's Commission on Nonepileptic Seizures, member ad hoc Task Force of the ILAE Commission on Therapeutic Strategies, member of the AES Suicidality Task Force, and steward for the NINDS Benchmarks in Epilepsy Research. Dr. Pardoe has received research support from NIH/NINDS. Dr. Fulbright has received research support from NIH/NINDS. Dr. Schuele has served on the scientific advisory board for Lundbeck Inc.; serves on the editorial board of Epileptic Disorders; serves on speakers' bureaus for GlaxoSmith Kline and UCB; and has received research support from NIH/NINDS. Dr. Jackson serves on a scientific advisory board for Neurosciences Victoria; receives royalties from the publication of Magnetic Resonance in Medicine, 2nd ed. (Elsevier 2005); and has received research support from NHMRC and NIH/NINDS." ]